UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Abstract Osteoarthritis (OA) progression is closely related to dysregulated glycolysis. As the primary metabolite of glycolysis, lactate plays a detrimental role in OA. However, how lactate exacerbates OA process remains unclear. Here, this study revealed that lactate levels are elevated in the syno...

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Egile Nagusiak:	Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Wiley 2025-05-01
Saila:	Advanced Science
Gaiak:	chondrocytes lactate lactylation osteoarthritis udp‐glucose dehydrogenase
Sarrera elektronikoa:	https://doi.org/10.1002/advs.202413709
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!