Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from <i>Fibrodysplasia Ossificans Progressiva</i> Patients

<i>Fibrodysplasia Ossificans Progressiva</i> (FOP) is a rare genetic disease characterized by heterotopic ossification (HO). It is caused by mutations in the Activin receptor type 1 (<i>ACVR1</i>) gene, resulting in enhanced responsiveness to ligands, specifically to Activin-A. Though it has been sh...

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Principais autores:	Ton Schoenmaker, Michal Mokry, Dimitra Micha, Coen Netelenbos, Nathalie Bravenboer, Marjolijn Gilijamse, E. Marelise W. Eekhoff, Teun J. de Vries
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-06-01
Series:	Biomedicines
Assuntos:	<i>fibrodysplasia ossificans progressiva</i> Activin-A periodontal ligament fibroblasts RNA sequencing heterotopic ossification
Acceso en liña:	https://www.mdpi.com/2227-9059/9/6/629
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