Dual-responsive chondroitin sulfate self-assembling nanoparticles for combination therapy in metastatic cancer cells

In this study, we developed self-assembling nanoparticles (LCPs) able to trigger the release of Chlorambucil (Chl) and Doxorubicin (DOX) to MDA-MB-231 cells by exploiting the enzyme and redox signals. The DOX loaded LCPs was prepared by the self-assembly of two chondroitin sulphate (CS) derivatives,...

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Bibliographic Details

Main Authors:	Ensieh Poursani, Giuseppe Cirillo, Manuela Curcio, Orazio Vittorio, Michele De Luca, Antonella Leggio, Fiore Pasquale Nicoletta, Francesca Iemma
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2024-06-01
Series:	International Journal of Pharmaceutics: X
Subjects:	Stimuli-responsive release Prodrugs Self-assembling nanoparticles Co-delivery
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590156724000070
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