P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis

Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry14 in human neurofibromas, neurofibroma-derived SC...

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Principais autores:	Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Ramya Ravindran, Jose A Cancelas, Robert J Spinner, Nancy Ratner
格式:	Artigo
語言:	Inglês
出版:	eLife Sciences Publications Ltd 2022-03-01
叢編:	eLife
主題:	neurofibromatosis type 1 NF1 Schwann cell precursors Schwann cell P2RY14 EGFR
在線閱讀:	https://elifesciences.org/articles/73511
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