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IL-4Rα signalling influences behavioural and immune responses in Trypanosoma brucei-infected mice: Evidence for iloprost as a neuroprotective agent

This study investigated the effects of Trypanosoma brucei infection on neuroinflammation, immune response, and behaviour in both wild-type (WT) and IL-4Rα inhibited (IL-4Rα┴) mice. To achieve this, 9-week-old WT and IL-4Rα┴ mice were infected with T. brucei intraperitoneally (5 ×102 parasites) and t...

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Principais autores: OS Olaolu, H. Davids, GB Dealtry, A.S. Abubakar, ET Obishakin, B. Iliyasu, IA Azeez, DC Ajonijebu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-12-01
coleção:IBRO Neuroscience Reports
Assuntos:
IL-4Rα┴
Trypanosomiasis
Neuroinflammation
Anxiety
Iloprost
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2667242125001307
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