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Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer

Abstract Background Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s to 10,000s per cell, thus providing a po...

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Principais autores: Yanni Li, Kristina Sundquist, Sakshi Vats, Mun-Gwan Hong, Xiao Wang, Yilun Chen, Anna Hedelius, Lao H. Saal, Jan Sundquist, Ashfaque A. Memon
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-10-01
Serier:Journal of Translational Medicine
Fag:
Breast cancer
mtDNA
Sequencing
Heteroplasmic mutation
ddPCR validation
Online adgang:https://doi.org/10.1186/s12967-023-04534-4
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