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Predictive value of baseline levels and early dynamic changes of ctDNA for 28-day mortality in ICU patients with advanced lung cancer: a prospective single-center cohort study

BackgroundCritically ill patients with advanced lung cancer admitted to the ICU have high short-term mortality and heterogeneous outcomes. Conventional severity measures reflect organ failure but not tumor-related activity.ObjectiveTo assess whether baseline ctDNA and 72-h ctDNA dynamics are associa...

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Principais autores: Liping Tan, Dongxi Lu, Haijiao Huang, Dongyi Lin, Dingwen Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-06-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
cancer biomarker
circulating tumor DNA
intensive care
lung cancer
prognostic model
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2026.1811387/full
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