Combined Metformin and Baricitinib Therapy Attenuates Inflammation in STZ‐Induced Diabetic Rats via AMPK/JAK–STAT Pathway Crosstalk

ABSTRACT Background Chronic inflammation is a critical factor contributing to diabetes complications. Baricitinib inhibits JAK–STAT signalling, which can contribute to an anti‐inflammatory effect. Similarly, metformin demonstrates anti‐inflammatory properties by activating the AMPK–SIRT pathway and...

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Autors principals:	Mostafa Allahyari, AbdolJalal Marjani, Marie Saghaeian Jazi, Mehrdad Jahanshahi
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-09-01
Col·lecció:	Endocrinology, Diabetes & Metabolism
Matèries:	AMPK baricitinib JAK–STAT metformin NF‐kB SIRT1
Accés en línia:	https://doi.org/10.1002/edm2.70101
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