Código QR

AAV-DJ is superior to AAV9 for targeting brain and spinal cord, and de-targeting liver across multiple delivery routes in mice

Abstract Highly efficient adeno associated viruses (AAVs) targeting the central nervous system (CNS) are needed to deliver safe and effective therapies for inherited neurological disorders. The goal of this study was to compare the organ-specific transduction efficiencies of two AAV capsids across t...

Descrición completa

Gardado en:
Principais autores: Monika Chauhan, Audrey L. Daugherty, Fatemeh (Ellie) Khadir, Ozgun F. Duzenli, Alexandra Hoffman, Jennifer A. Tinklenberg, Peter B. Kang, George Aslanidi, Christina A. Pacak
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-09-01
Series:Journal of Translational Medicine
Assuntos:
AAV capsids
AAV9
AAV-DJ
Gene therapy
Intravenous
Intrathecal
Acceso en liña:https://doi.org/10.1186/s12967-024-05599-5
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares