Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma

TM-2 known as a potential antitumor drug is a novel semi-synthetic taxane derivative. As drug–protein interactions contribute to insights into pharmacokinetic and pharmacodynamic properties, we elucidated the binding of TM-2 to plasma protein. In this study, a simple, rapid and reliable method was d...

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Detalles Bibliográficos

Principais autores:	Hui Liu, Pan-Pan Wu, Ming-Jing Yang, Lei Men, Hong-Li Lin, Yun-Li Zhao, Xing Tang, Zhi-Guo Yu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2016-02-01
Series:	Journal of Pharmaceutical Analysis
Assuntos:	TM-2 Plasma protein binding UPLC–MS/MS
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2095177915300058
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