Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options

Abstract Background Being the standard-of-care for four decades, cisplatin-based chemotherapy is highly efficient in treating germ cell tumors (GCT). However, often refractory patients present with a remaining (resistant) yolk-sac tumor (YST(-R)) component, resulting in poor prognosis due to lack of...

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Hlavní autoři:	Margaretha A. Skowron, Mara Kotthoff, Felix Bremmer, Katja Ruhnke, Fatma Parmaksiz, Annika Richter, Stefan Küffer, Kirsten Reuter-Jessen, Stella Pauls, Anja Stefanski, Philipp Ströbel, Kai Stühler, Daniel Nettersheim
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-03-01
Edice:	Molecular Medicine
Témata:	Germ cell tumors Yolk-sac tumor Therapy Resistance CLDN6 Antibody-drug-conjugate
On-line přístup:	https://doi.org/10.1186/s10020-023-00636-3
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