Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons

Abstract Phosphatidylserine (PS) asymmetry in plasma membranes is critical for cellular functions and serves as an apoptotic signal in many cell types. However, in mature neurons, the molecular mechanisms governing PS distribution, its precise regulation, and its functional significance beyond apopt...

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Bibliographic Details

Main Authors:	Adriana Schneider, Alexandra B. Merkel, Nunzio Perta, Lisa Ruff, Netta Ussyshkin, Paula Zimmer, Bahar Aksan, Amandine Lepeuve, Laura D’Andrea, Silvia Pelucchi, Elena Marcello, Daniele Di Marino, Daniela Mauceri
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2026-07-01
Series:	Cell Death and Disease
Online Access:	https://doi.org/10.1038/s41419-026-09097-y
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