Reduced Clinical Target Volume Margins in Glioblastoma: Exploratory Evidence Supporting Further Margin Reduction Independent of MGMT Status

<b>Background:</b> Clinical target volume (CTV) delineation in glioblastoma remains debated, particularly in the era of modern chemoradiation and image-guided radiotherapy. Whether reduced CTV margins can preserve oncological outcomes without increasing marginal or out-of-field failures remains unce...

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Detalhes bibliográficos

Principais autores:	Flavio Donnini, Giuseppe Minniti, Salvatore Chibbaro, Giulio Bagnacci, Armando Perrella, Giuseppe Battaglia, Giovanni Rubino, Pierpaolo Pastina, Tommaso Carfagno, Marta Vannini, Maria Antonietta Mazzei, Alfonso Cerase, Paolo Tini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-04-01
Colecção:	Brain Sciences
Assuntos:	glioblastoma radiotherapy clinical target volume margin reduction target margins recurrence patterns
Acesso em linha:	https://www.mdpi.com/2076-3425/16/5/458
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