The dihydropyridine LA1011 modulates multiple Hsp90—co-chaperone interactions relevant to Alzheimer’s disease

LA1011 (dimethyl 4-(4-Trifluoro-methyl-phenyl)-2,6-bis(2-dimethylamino-ethyl)-1-methyl-1-4 dihydropyridine-3-5-dicarboxylate dihydrochloride) has been shown to improve the prognosis of Alzheimer’s disease (AD) in an APPxPS1 mouse model. The target for LA1011 is the C-terminal domain of Hsp90, where...

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Auteurs principaux:	Xavier Jeanne, Jasmeen Oberoi, Mark S. Roe, Matthias Baud, John Spencer, Zsolt Torok, Laszlo Vigh, Chrisostomos Prodromou
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2026-02-01
Collection:	Cell Stress & Chaperones
Sujets:	Hsp90 Co-chaperones Proteostasis Hsp90 allosteric compounds Alzheimer’s disease
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S1355814525000768
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