Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis.

The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) and stabilises the mature viral core, whereas defects in the C-terminal domain (CTD) of p12 can be rescued by additi...

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Detalhes bibliográficos

Principais autores:	Madushi Wanaguru, David J Barry, Donald J Benton, Nicola J O'Reilly, Kate N Bishop
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2018-06-01
coleção:	PLoS Pathogens
Acesso em linha:	https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.ppat.1007117/2/ppat.1007117.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210216%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210216T100823Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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