Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors

A series of hydrazine-1-carbothioamides derivatives (<b>3a</b>–<b>3j</b>) were synthesized and analyzed for inhibitory potential towards bovine carbonic anhydrase II (<i>b</i>-CA II) and 15-lipoxygenase (15-LOX). Interestingly, four derivatives, <b>3b</b>, <b>3d</b>, <b>3g</b>, and <b>3j</b>, were f...

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Principais autores:	Pervaiz Ali Channar, Rima D. Alharthy, Syeda Abida Ejaz, Aamer Saeed, Jamshed Iqbal
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2022-12-01
Serija:	Molecules
Teme:	carbonic anhydrase II 15-lipoxygenase docking studies thiourea simulation
Online dostop:	https://www.mdpi.com/1420-3049/27/24/8723
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