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Analysis of β-catenin association with obesity in African Americans with premalignant and malignant colorectal lesions

Abstract Background African Americans (AA) are at high risk for Colorectal Cancer (CRC). Studies report a 30–60% increase in CRC risk with physical inactivity, obesity and metabolic syndrome. Activation of the WNT/β-catenin (CTNNB1) signaling pathway plays a critical role in colorectal carcinogenesi...

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Principais autores: Babak Shokrani, Hassan Brim, Tahmineh Hydari, Ali Afsari, Edward Lee, Mehdi Nouraie, Zaki Sherif, Hassan Ashktorab
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-08-01
coleção:BMC Gastroenterology
Assuntos:
β-Catenin
Colorectal cancer
Advanced adenoma
African Americans
Acesso em linha:http://link.springer.com/article/10.1186/s12876-020-01412-x
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