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Ethers and esters derived from apocynin avoid the interaction between p47phox and p22phox subunits of NADPH oxidase: evaluation in vitro and in silico

NOX (NADPH oxidase) plays an important role during several pathologies because it produces the superoxide anion (O2•−), which reacts with NO (nitric oxide), diminishing its vasodilator effect. Although different isoforms of NOX are expressed in ECs (endothelial cells) of blood vessels,...

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Principais autores: Lowell Kispert, Jessica Elena Mendieta‑Wejebe, Martha Cecilia Rosales‑Hernández, José Correa‑Basurto, Federico Martínez‑Ramos, Itzia Irene Padilla‑Martínez, Martha Edith Macías‑Pérez
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press 2013-08-01
Serier:Bioscience Reports
Fag:
apocynin derivatives
drug design
inhibitory activity
molecular modelling
NADPH oxidase
Online adgang:http://www.bioscirep.org/bsr/033/e055/bsr033e055.htm
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