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Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats

Oxidative stress and inflammation damage play pivotal roles in vascular dementia (VaD). Trimethylamine N-oxide (TMAO), an intestinal microbiota-stemming metabolite, was reported to promote inflammation and oxidative stress, involved in the etiology of several diseases. Still, these effects have not...

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Principais autores: Yang Deng, Junqing Zou, Ye Hong, Qiang Peng, Xinxin Fu, Rui Duan, Jie Chen, Xiangliang Chen
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-11-01
Series:Cells
Assuntos:
trimethylamine N-oxide
SIRT1
inflammation
oxidative stress
synaptic plasticity
vascular dementia
Acceso en liña:https://www.mdpi.com/2073-4409/11/22/3650
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