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Single-cell RNA sequencing uncovers heterogeneous transcriptional signatures in tumor-infiltrated dendritic cells in prostate cancer

Prostate cancer (PCa) is one of the two solid malignancies in which a higher T cell infiltration in the tumor microenvironment (TME) corresponds with a worse prognosis for the tumor. The inability of T cells to eliminate tumor cells despite an increase in their number reinforces the possibility of i...

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Main Authors: Adib Miraki Feriz, Arezou Khosrojerdi, Mohammad Lotfollahi, Neusha Shamsaki, Mohammad GhasemiGol, Edris HosseiniGol, Mohammad Fereidouni, Mohammad Hossein Rohban, Ahmad Reza Sebzari, Samira Saghafi, Patrizia Leone, Nicola Silvestris, Hossein Safarpour, Vito Racanelli
Format: Artigo
Language:Inglês
Published: Elsevier 2023-05-01
Series:Heliyon
Subjects:
Prostate cancer
Tumor microenvironment
Dendritic cells
Immunotherapy
Single-cell RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023029018
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