A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages

Abstract Osteoarthritis (OA) affects the entire knee joint, yet cross-tissue molecular interplay remains poorly understood. To address this, we constructed the first single-cell RNA sequencing atlas of knee OA, profiling articular cartilage, meniscus, synovium, and subchondral bone. Our analysis rev...

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Detalhes bibliográficos

Principais autores:	Rajnikant Dilip Raut, Amit Kumar Chakraborty, Tuhina Neogi, Michael Albro, Brian Snyder, Thomas P. Schaer, Chao Zhang, Mark W. Grinstaff, Manish V. Bais
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-08-01
coleção:	Communications Biology
Acesso em linha:	https://doi.org/10.1038/s42003-025-08586-8
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