Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation
N6-methyladenosine (m6A) is the most abundant internal modification on eukaryotic mRNAs. Demethylation of m6A on mRNA is catalyzed by the enzyme fat mass and obesity-associated protein (FTO), a member of the nonheme Fe(II) and 2-oxoglutarate (2-OG)-dependent family of dioxygenases. FTO activity and...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Elsevier
2023-11-01
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| Seria: | Redox Biology |
| Dostęp online: | http://www.sciencedirect.com/science/article/pii/S2213231723003294 |
| Etykiety: |
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