Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases

Interleukin 7 (IL-7) is a cell growth factor with a central role in normal T cell development, survival and differentiation. The lack of IL-7–IL-7 receptor(R)-mediated signaling compromises lymphoid development, whereas increased signaling activity contributes to the development of chronic inflammat...

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Bibliografiske detaljer

Principais autores:	Jennifer Vandooren, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Vasily Rybakin, Sam Noppen, Melissa R. Stas, Eline Bernaerts, Eva Ganseman, Mieke Metzemaekers, Dominique Schols, Paul Proost, Ghislain Opdenakker
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2021-06-01
Serier:	Frontiers in Immunology
Fag:	IL-7 matrix metalloproteinase-9 proteolysis signal transduction proliferation neutrophils
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.701739/full
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