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Steering CAR T cells to distinguish friend from foe

CD19-specific chimeric antigen receptor (CAR)+ T cells have demonstrated clinical efficacy and long-lasting remissions, concomitant with tolerable normal B-cell aplasia. However, many tumor-associated antigens (TAAs) are expressed on normal tissues, the destruction of which would lead to intolerable...

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Bibliografische gegevens
Hoofdauteurs: Hillary G. Caruso, Amy B. Heimberger, Laurence J. N. Cooper
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis Group 2019-10-01
Reeks:OncoImmunology
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Online toegang:http://dx.doi.org/10.1080/2162402X.2016.1271857
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