Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study

BackgroundRenal cell carcinoma (RCC) is characterized by a high degree of genomic but also functional intratumoral heterogeneity (ITH). Mutations in VHL, chromatin remodeling genes such as SETD2 and genes that regulate the PI3K/AKT/mTOR pathway have been identified as recurrent drivers despite genom...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Jakob Wieke, Christina Jurcic, Adam Kaczorowski, Sarah Böning, Martina Kirchner, Constantin Schwab, Viktoria Schütz, Markus Hohenfellner, Anette Duensing, Albrecht Stenzinger, Stefan Duensing
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2025-04-01
Цуврал:	Frontiers in Oncology
Нөхцлүүд:	renal cell carcinoma tumor heterogeneity genotype phenotype VHL mTOR
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1551077/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!