Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease

Abstract INTRODUCTION The aggregation and spread of hyperphosphorylated, pathological tau in the human brain is hypothesized to play a key role in Alzheimer's disease (AD) as well as other neurogenerative tauopathies. O‐GlcNAcylation, an important post‐translational modification of tau and many othe...

Celý popis

Podrobná bibliografie

Hlavní autoři:	William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2024-10-01
Edice:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Témata:	Alzheimer's disease enzyme occupancy O‐GlcNAcase inhibition O‐GlcNAcylation pharmacokinetics tau
On-line přístup:	https://doi.org/10.1002/trc2.70020
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!