The molecular determinants of R-roscovitine block of hERG channels.
Human ether-à-go-go-related gene (Kv11.1, or hERG) is a potassium channel that conducts the delayed rectifier potassium current (IKr) during the repolarization phase of cardiac action potentials. hERG channels have a larger pore than other K+channels and can trap many unintended drugs, often resulti...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Public Library of Science (PLoS)
2019-01-01
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| سلاسل: | PLoS ONE |
| الوصول للمادة أونلاين: | https://doi.org/10.1371/journal.pone.0217733 |
| الوسوم: |
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