Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Abstract Background Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2 (LMP2) in the pathophysiology of ischemia stroke. However, the...

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主要な著者:	Xing-Yong Chen, Shao-Fen Wan, Nan-Nan Yao, Ze-Jing Lin, Yan-Guang Mao, Xiao-Hua Yu, Yin-Zhou Wang
フォーマット:	Artigo
言語:	Inglês
出版事項:	KeAi Communications Co., Ltd. 2021-12-01
シリーズ:	Military Medical Research
主題:	Immunoproteasome Blood–brain barrier Wnt/β-catenin pathway Oxygen–glucose deprivation/reperfusion Cerebral ischemia
オンライン･アクセス:	https://doi.org/10.1186/s40779-021-00356-x
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