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In vivo Downregulation of MHC Class I Molecules by HCMV Occurs During All Phases of Viral Replication but Is Not Always Complete

Based on cell culture data, MHC class I downregulation by HCMV on infected cells has been suggested as a means of immune evasion by this virus. In order to address this issue in vivo, an immunohistochemical analysis of tissue sections from biopsy and autopsy materials of HCMV infected organs was per...

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Detalhes bibliográficos
Principais autores: Florin Gabor, Gerhard Jahn, Daniel D. Sedmak, Christian Sinzger
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-06-01
Colecção:Frontiers in Cellular and Infection Microbiology
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fcimb.2020.00283/full
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