Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet.

<h4>Background</h4>Methylation at C-5 (5-mdC) of CpG base pairs, the most abundant epigenetic modification of DNA, is catalyzed by 3 essential DNA methyltransferases (Dnmt1, Dnmt3a and Dnmt3b). Aberrations in DNA methylation and Dnmts are linked to different diseases including cancer. However, their...

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Hlavní autoři:	Huban Kutay, Corie Klepper, Bo Wang, Shu-hao Hsu, Jharna Datta, Lianbo Yu, Xiaoli Zhang, Sarmila Majumder, Tasneem Motiwala, Nuzhat Khan, Martha Belury, Craig McClain, Samson Jacob, Kalpana Ghoshal
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2012-01-01
Edice:	PLoS ONE
On-line přístup:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041949&type=printable
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