Microbiota shape the colon epithelium controlling inter-crypt absorptive goblet cells via butyrate–GP R109A signalling

The colonic epithelium is a key interface between the gut microbiota and the host. How microbiota-derived signals influence epithelial cell identity and function remains incompletely understood. Here, we used single-cell transcriptomics, antibiotic-mediated microbiota depletion, germ-free mice and c...

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Detalhes bibliográficos

Principais autores:	Vinícius Dias Nirello, Nathália Araújo, Helder Carvalho de Assis, Mar Moreno-Gonzalez, Paula Ruiz, Pollyana Ribeiro Castro, Nicolas G. Shealy, Catherine Shelton, Mariane Font Fernandes, Sarah de Oliveira, Mariana Boroni, Bernhard Ryffel, Mariana Xavier Byndloss, Naiara Beraza, Marco Aurélio Ramirez Vinolo, Patrick Varga-Weisz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2025-12-01
coleção:	Gut Microbes
Assuntos:	Single-cell transcriptomics colon epithelium butyrate GPR109A HCAR2 aging
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/19490976.2025.2573045
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