Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat

BackgroundDiabetic nephropathy (DN) is a severe complication of diabetes, which has been increasingly associated with gut microbiota dysbiosis and inflammatory dysregulation.ObjectiveThis study investigates the dual therapeutic potential of diosgenin (DIO), a steroidal sapogenin, in modulating the g...

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Main Authors: Jiang Shanshan, Pan Shu, Hu Xiao, Kudelaidi Kuerban, Zhu Hao, Wang Yujie, Wang Rong, Shi Yuhuan, Yuan Yongfang
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Assuntos:
diosgenin
anti-inflammatory
gut microbiota
diabetic nephropathy
NLRP3 inflammasome
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555849/full
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