Interaction between Poly(ADP-ribose) polymerase-1 and α-synuclein pathology in Parkinson’s disease

Poly(ADP-ribose) polymerase-1 (PARP-1) activation and α-synuclein (α-syn) aggregation are neuropathological hallmarks of Parkinson’s disease. This review aims to summarize the extensive interplay between these two factors. PARP-1 induces conformational changes in α-syn through structural reorganizat...

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Detalhes bibliográficos

Principais autores:	Peng Zhang, Qinghua Li, Xiaojun Diao, Sihao Zeng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Neuroscience
Assuntos:	neurodegeneration oxidative stress Parkinson’s disease PARP-1 Poly(ADP-ribose) Poly(ADP-Ribose) Polymerase-1
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1774158/full
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