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A DNA methylation signature identified in the buccal mucosa reflecting active tuberculosis is changing during tuberculosis treatment

Abstract Tuberculosis (TB) poses a significant global health threat, with high mortality rates if left untreated. Current sputum-based TB treatment monitoring methods face numerous challenges, particularly in relation to sample collection and analysis. This pilot study explores the potential of TB s...

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Principais autores: Isabelle Öhrnberg, Lovisa Karlsson, Shumaila Sayyab, Jakob Paues, David Martínez-Enguita, Mika Gustafsson, Patricia Espinoza-Lopez, Melissa Méndez-Aranda, Ericka Meza, Cesar Ugarte-Gil, Nicholas Kiprotich, Lameck Diero, Ronald Tonui, Maria Lerm
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-11-01
Serier:Scientific Reports
Fag:
Tuberculosis
Treatment monitoring
Oral swabs
DNA methylation
Biosignatures
Buccal mucosa
Online adgang:https://doi.org/10.1038/s41598-024-80570-4
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