Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest and differentiation of the tumor cells. Here, we...

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主要な著者:	Franziska Eckert, Ivan Jelas, Moritz Oehme, Stephan M. Huber, Katja Sonntag, Christian Welker, Stephen D. Gillies, Wolfgang Strittmatter, Daniel Zips, Rupert Handgretinger, Karin Schilbach
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis Group 2017-06-01
シリーズ:	OncoImmunology
主題:	differentiation glioma il12 immunocytokine radiotherapy rhabdomyosarcoma senescence
オンライン･アクセス:	http://dx.doi.org/10.1080/2162402X.2017.1323161
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