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Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer

Abstract Background Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory mechanism in non-small cell lung cancer (NSCLC) is not well understood. Pyruvate dehydrogenase kinase 4 (PDK4), a central...

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Principais autores: Xiyu Liu, Jingjing Li, Qingqing Huang, Mingming Jin, Gang Huang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-04-01
coleção:Molecular Medicine
Assuntos:
Ginsenoside Rh2
NSCLC
PDK4
Glycolysis
Oxidative phosphorylation
Acesso em linha:https://doi.org/10.1186/s10020-024-00813-y
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