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Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation

Solid organ transplantation is the treatment of choice for various end-stage diseases, but requires the continuous need for immunosuppression to prevent allograft rejection. This comes with serious side effects including increased infection rates and development of malignancies. Thus, there is a cli...

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Principais autores: Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
coleção:Frontiers in Immunology
Assuntos:
CAR (chimeric antigen receptor)
Tregs (regulatory T cells)
transplantation
antigen specificity
cellular therapy
tolerance
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.874157/full
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