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Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles

DNA methylation is recognized as one of several epigenetic regulators of gene expression and as potential driver of carcinogenesis through gene-silencing of tumor suppressors and activation of oncogenes. However, abnormal methylation, even of promoter regions, does not necessarily alter gene express...

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Hoofdauteurs: Hagen Klett, Yesilda Balavarca, Reka Toth, Biljana Gigic, Nina Habermann, Dominique Scherer, Petra Schrotz-King, Alexis Ulrich, Peter Schirmacher, Esther Herpel, Hermann Brenner, Cornelia M. Ulrich, Karin B. Michels, Hauke Busch, Melanie Boerries
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis Group 2018-04-01
Reeks:Epigenetics
Onderwerpen:
epigenetic regulation
colorectal cancer
dna methylation
gene expression
prediction model
hmga1
Online toegang:http://dx.doi.org/10.1080/15592294.2018.1460034
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