Impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of lenvatinib in patients with hepatocellular carcinoma

This prospective study examined the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HCC). Pharmacokinetic studies were performed at the...

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Detalhes bibliográficos
Main Authors: Hironao Okubo, Hitoshi Ando, Kei Ishizuka, Jun-ichi Morishige, Kenichi Ikejima, Shuichiro Shiina, Akihito Nagahara
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-01-01
Colecção:Journal of Pharmacological Sciences
Assuntos:
Lenvatinib
Pharmacokinetic study
Polymorphism
Adverse event
Hepatocellular carcinoma
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1347861321000864
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