Impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of lenvatinib in patients with hepatocellular carcinoma

This prospective study examined the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HCC). Pharmacokinetic studies were performed at the...

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Autors principals:	Hironao Okubo, Hitoshi Ando, Kei Ishizuka, Jun-ichi Morishige, Kenichi Ikejima, Shuichiro Shiina, Akihito Nagahara
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-01-01
Col·lecció:	Journal of Pharmacological Sciences
Matèries:	Lenvatinib Pharmacokinetic study Polymorphism Adverse event Hepatocellular carcinoma
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1347861321000864
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