Inhibiting 5‐lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin‐like growth factor‐1

Abstract Background Skeletal muscle atrophy can occur in response to numerous factors, such as ageing and certain medications, and produces a major socio‐economic burden. At present, there are no approved drugs for treating skeletal muscle atrophy. Arachidonate 5‐lipoxygenase (Alox5) is a drug targe...

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Үндсэн зохиолчид:	Hyun‐Jun Kim, Seon‐Wook Kim, Sang‐Hoon Lee, Da‐Woon Jung, Darren R. Williams
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley 2022-12-01
Цуврал:	Journal of Cachexia, Sarcopenia and Muscle
Нөхцлүүд:	Skeletal muscle atrophy Malotilate Alox5 Drug repurposing Glucocorticoids Sarcopenia
Онлайн хандалт:	https://doi.org/10.1002/jcsm.13092
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!