Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents

Solid tumours are often poorly oxygenated, which confers resistance to standard treatment modalities. Targeting hypoxic tumours requires compounds, such as nitroimidazoles (NIs), equipped with the ability to reach and become activated within diffusion limited tumour niches. NIs become selectively en...

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Bibliographic Details

Main Authors:	Faisal Bin Rashed, Diana Diaz-Dussan, Fatemeh Mashayekhi, Dawn Macdonald, Patrick Nicholas Nation, Xiao-Hong Yang, Sargun Sokhi, Alexandru Cezar Stoica, Hassan El-Saidi, Carolynne Ricardo, Ravin Narain, Ismail Hassan Ismail, Leonard Irving Wiebe, Piyush Kumar, Michael Weinfeld
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2022-06-01
Series:	Redox Biology
Subjects:	Hypoxia Nitroimidazole Head and neck tumour Replication stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231722000726
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