A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir

Summary: Quantifying the replication-competent HIV reservoir is essential for evaluating curative strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to induce all replication-competent proviruses. Single- or double-region HIV DNA assays overestimate it because th...

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Auteurs principaux:	Claire N. Levy, Sean M. Hughes, Pavitra Roychoudhury, Daniel B. Reeves, Chelsea Amstuz, Haiying Zhu, Meei-Li Huang, Yulun Wei, Marta E. Bull, Noah A.J. Cassidy, Jan McClure, Lisa M. Frenkel, Mars Stone, Sonia Bakkour, Elizabeth R. Wonderlich, Michael P. Busch, Steven G. Deeks, Joshua T. Schiffer, Robert W. Coombs, Dara A. Lehman, Keith R. Jerome, Florian Hladik
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2021-04-01
Collection:	Cell Reports Medicine
Sujets:	HIV cure HIV reservoir digital PCR multiplexing viral outgrowth assay intact proviral DNA assay
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2666379121000598
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