ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects. However, COL4A1 renal disease remains poorly characterized and its pathomolecular mechanisms a...

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Detalhes bibliográficos

Principais autores:	Frances E. Jones, Matthew A. Bailey, Lydia S. Murray, Yinhui Lu, Sarah McNeilly, Ursula Schlötzer-Schrehardt, Rachel Lennon, Yoshikazu Sado, David G. Brownstein, John J. Mullins, Karl E. Kadler, Tom Van Agtmael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Company of Biologists 2016-02-01
coleção:	Disease Models & Mechanisms
Assuntos:	Collagen IV Extracellular matrix Endoplasmic reticulum stress Basement membrane Kidney disease
Acesso em linha:	http://dmm.biologists.org/content/9/2/165
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