Regulation of cardiac ryanodine receptor function by the cyclic-GMP dependent protein kinase G

Background: The cGMP-dependent protein kinase G (PKG) phosphorylates the cardiac ryanodine receptor (RyR2) in vitro. We aimed to determine whether modulation of endogenous PKG alters RyR2-mediated spontaneous Ca2+ release and whether this effect is linked to a change in RyR2 phosphorylation. Methods...

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Autors principals:	Luis A. Gonano, Hamish M. Aitken-Buck, Akash D. Chakraborty, Luke P.I. Worthington, Tanya R. Cully, Regis R. Lamberts, Martin G. Vila-Petroff, Peter P. Jones
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-01-01
Col·lecció:	Current Research in Physiology
Matèries:	Protein kinase G Cardiac ryanodine receptor Phosphorylation Calcium Store overload-induced calcium release KT 5823
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2665944122000165
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