Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD

There is a low efficiency of A-to-G base conversion in at specific positions using base editors. Here the authors fuse ABE8e with the Rad51 DNA-binding domain to generate a hyperactive ABE allowing improved A-to-G editing efficiency at the region proximal to the PAM and improved simultaneous A/C con...

詳細記述

書誌詳細

主要な著者:	Niannian Xue, Xu Liu, Dan Zhang, Youming Wu, Yi Zhong, Jinxin Wang, Wenjing Fan, Haixia Jiang, Biyun Zhu, Xiyu Ge, Rachel V. L. Gonzalez, Liang Chen, Shun Zhang, Peilu She, Zhilin Zhong, Jianjian Sun, Xi Chen, Liren Wang, Zhimin Gu, Ping Zhu, Mingyao Liu, Dali Li, Tao P. Zhong, Xiaohui Zhang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2023-03-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-023-36887-1
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!