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The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells

Background and objective: A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum Ca2+-ATPase (SERCA) and generating heat from ATP hydrolysis to be a promising strategy to counteract obesity and metabol...

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Furkejuvvon:
Váldodahkkit: Abel M. Mengeste, Jenny Lund, Parmeshwar Katare, Roya Ghobadi, Hege G. Bakke, Per Kristian Lunde, Lars Eide, Gavin O’ Mahony, Sven Göpel, Xiao-Rong Peng, Eili Tranheim Kase, G. Hege Thoresen, Arild C. Rustan
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2021-01-01
Ráidu:Current Research in Pharmacology and Drug Discovery
Fáttát:
Obesity
Type 2 diabetes
Skeletal muscle
SERCA
Glucose metabolism
Lipid metabolism
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S259025712100047X
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