ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma

Abstract Background Increasing evidence support an important role for DNA methylation in nasopharyngeal carcinoma (NPC). Here, we explored the role of circadian clock gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL) methylation in NPC. Methods We employed bisulfite pyrosequencing to...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Hao Peng, Jian Zhang, Pan-Pan Zhang, Lei Chen, Ling-Long Tang, Xiao-Jing Yang, Qing-Mei He, Xin Wen, Ying Sun, Na Liu, Ying-Qin Li, Jun Ma
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2019-01-01
Serie:	Journal of Experimental & Clinical Cancer Research
Soggetti:	Nasopharyngeal carcinoma ARNTL Methylation Proliferation CDK5 Chemotherapy sensitivity
Accesso online:	http://link.springer.com/article/10.1186/s13046-018-0997-7
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!