TAp63γ is the primary isoform of TP63 for tumor suppression but not development

Abstract TP63 is expressed as TAp63 and ΔNp63 from the P1 and P2 promoters, respectively. While TAp63 and ΔNp63 are expressed as three TAp63α/β/γ and ΔNp63α/β/γ due to alternative splicing, only p63α (TA and ΔN) and p63γ (TA and ΔN) proteins are found to be detectable and likely to be responsible fo...

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Үндсэн зохиолчид:	Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Publishing Group 2025-02-01
Цуврал:	Cell Death Discovery
Онлайн хандалт:	https://doi.org/10.1038/s41420-025-02326-x
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!