Dynamic evolution of the sofosbuvir-associated variant A1343V in HEV-infected patients under concomitant sofosbuvir-ribavirin treatment

Background & Aims: In the absence of a hepatitis E virus (HEV)-specific antiviral treatment, sofosbuvir has recently been shown to have antiviral activity against HEV in vivo. However, a variant, A1343V, that is strongly associated with viral relapse impedes treatment success. In this study, we...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	André Gömer, Katja Dinkelborg, Mara Klöhn, Michelle Jagst, Michael Hermann Wißing, Nicola Frericks, Pia Nörenberg, Patrick Behrendt, Markus Cornberg, Heiner Wedemeyer, Eike Steinmann, Benjamin Maasoumy, Daniel Todt
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-03-01
Schriftenreihe:	JHEP Reports
Schlagworte:	Viral RNA-directed RNA polymerase inhibitors high-throughput sequencing resistance profiling intra-host evolution
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589555923003208
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!