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Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation

ABSTRACT Multiple pathogens, including viruses and bacteria, manipulate endoplasmic reticulum-associated degradation (ERAD) to avoid the host immune response and promote their replication. The betaretrovirus mouse mammary tumor virus (MMTV) encodes Rem, which is a precursor protein that is cleaved i...

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Principais autores: Hyewon Byun, Poulami Das, Houqing Yu, Alejandro Aleman, Mary M. Lozano, Andreas Matouschek, Jaquelin P. Dudley
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017-05-01
coleção:mBio
Assuntos:
ERAD
retrotranslocation
retrovirus
signal peptide
Acesso em linha:https://journals.asm.org/doi/10.1128/mBio.00328-17
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